Pfizer backs protein degrader drugs with Arvinas deal

Pfizer is investing $1 billion (£716 million) in Yale University spin-out Arvinas to commercialise the protein degrader drug ARV-471. The deal comprises a $350 million equity investment, giving Pfizer about 7% ownership of Arvinas, plus $650 million cash up front and milestone payments. The two companies already had a licensing deal, agreed in 2018. ARV-471 […]

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Metal sandwich stabilises first benzene triplet-state aromatic

Show Fullscreen A benzene diradical dianion stabilised by two gadolinium ions on either side is the first simple molecule that is Baird aromatic in the ground state. Baird aromaticity typically exists only in high-energy, excited state systems. A straightforward way to identify simple aromatic molecules is by their π electron count. If they have 4n+2 […]

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Fatal chemical leak at a Texas chemicals facility

An investigation is underway into what caused a fatal leak of approximately 100,000 pounds (45,359kg) of a mixture of chemicals – including acetic acid, methyl iodide and hydrogen iodide – from a LyondellBasell plant in La Porte, Texas, US, on 27 July. The chemical release killed two contractors working on-site and sent another 30 people […]

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Levitating glass bead closes in on quantum mechanics’ fundamental limit

The motion of an optically trapped glass bead has been slowed down to the state of lowest possible energy using two methods developed independently by teams in Austria and Switzerland. ‘These two works achieved the highest precision in controlling and measuring levitated nanoparticle optomechanical systems close to the Heisenberg limit, which is the ultimate bound […]

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Reliability of researcher metric the h-index is in decline

Changing authorship patterns mean that the h-index is no longer an effective way to gauge a scientist’s impact, according to a new study by data scientists at technology giant Intel. First created in 2005 by the US-based physicist Jorge Hirsch, the h-index is a measure of a researcher’s most highly cited papers. A scientist with […]

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Deadly explosion and fire at chemicals park in Germany

At least two workers were killed, and a further 31 injured, in an explosion and fire at a chemicals park in Leverkusen, Germany. Five people are still missing, and one of the injured is in a life-threatening condition. The explosion, whose cause is currently unknown, happened in the morning of 27 July. The incident set […]

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Observing the life and death of a single excited-state molecule

Researchers have observed electrons jumping between different energy levels in an individual molecule, and how the jumps can be suppressed when the excess energy is transferred instead to a nearby oxygen molecule – a process called quenching. By positioning the two molecules on a surface with atomic precision, the team could study how quenching is […]

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China unveils new measures to boost the number of women in science

China’s government plans to implement a raft of new measures to support women working in science and increase the number of women working in senior research roles. Despite making up 46% of China’s science and technology workforce, women continue to face disproportionate career barriers and are significantly underrepresented in senior roles. Only 6% of the […]

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Transient spectroscopy sheds light on elusive photoredox process

Researchers have provided spectroscopic evidence for the mechanism of a two-photon photoredox process known as sensitisation-initiated electron transfer, or SenI-ET.1 They applied transient absorption and emission spectroscopy to an iridium-based photosensitiser–catalyst couple, which allowed them to identify the active catalytic species – a short-lived pyrenyl radical anion – for the first time. The researchers hope […]

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Renaissance Science – XV

Vitruvius’ De architectura was by no means the only book rediscovered from antiquity that dealt with the construction and use of machines and the Renaissance artist-engineers were also not the only authors producing new texts on machines. In this episode of our series, we are going to look at another stream of writings that led to some […]

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