A new organocatalytic process has surfaced as a more straightforward technique for synthesizing phosphorothioate oligonucleotides, which are vital elements in RNA-centric therapies. These structures substitute an oxygen atom in the phosphate backbone with sulfur, improving cellular uptake and resistance to breakdown. The synthesis generally produces chiral phosphorus atoms, generating two stereospecific linkages that influence biological effectiveness. Conventional methods rely on chiral auxiliaries, which are resource-heavy and unwieldy.<\/p>\n
Nonetheless, investigators from Shanghai Jiao Tong University, under the leadership of Ming Shang, have pioneered the use of a chiral catalyst that eliminates the requirement for auxiliary guides. This catalyst harnesses a network of hydrogen bonds to position phosphorus reagents and nucleosides, guaranteeing accurate stereochemistry throughout oligomer construction. This technique originated from carbon-bond forming catalysts initially created by Jeffrey Johnston\u2019s group, representing a notable advancement in selective phosphorothioate synthesis.<\/p>\n
The approach has been effectively tested on various nucleoside combinations, yielding a range of phosphorus bonds and accommodating automated synthesis methods. This innovation not only simplifies production but may also shed light on the role of phosphorus stereochemistry in drug effectiveness, potentially resulting in improved nucleic acid therapeutics.<\/p>\n","protected":false},"excerpt":{"rendered":"
A new organocatalytic process has surfaced as a more straightforward technique for synthesizing phosphorothioate oligonucleotides, which are vital elements in RNA-centric therapies. These structures substitute an oxygen atom in the phosphate backbone with sulfur, improving cellular uptake and resistance to breakdown. The synthesis generally produces chiral phosphorus atoms, generating two stereospecific linkages that influence biological […]<\/p>\n","protected":false},"author":2,"featured_media":375304,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[174],"class_list":["post-375303","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-source-chemistryworld-com"],"_links":{"self":[{"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/posts\/375303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=375303"}],"version-history":[{"count":0,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/posts\/375303\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=\/wp\/v2\/media\/375304"}],"wp:attachment":[{"href":"https:\/\/wolfscientific.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=375303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=375303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wolfscientific.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=375303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}