At the recent spring gathering of the American Chemical Society (ACS), three Nobel Prize winners convened to impart their perspectives and experiences in surmounting challenges to emerge as leaders in the scientific arena. The roundtable included Jennifer Doudna, who received the Nobel Prize in 2020 for her work on Crispr–Cas9 genome editing; David MacMillan, who was jointly awarded the prize in 2021 for his research in asymmetric organocatalysis; and Omar Yaghi, honored last year for his co-creation of metal–organic frameworks (MOFs).
**A Failure That Yielded Success**
Omar Yaghi recounted his moments in graduate school where he encountered repeated setbacks in a seemingly simple de-coordination reaction, which led him to question his journey in chemistry. Nonetheless, he persisted and ultimately found success, showcasing that failures can precede significant breakthroughs. A key moment arose when a previously elusive reaction crystallized, reaffirming his dedication to his passion.
Jennifer Doudna discussed her challenges in adapting to the rigorous chemistry program at Pomona College, particularly after moving from a public high school in Hawaii that lacked comparable preparatory courses. Motivated by her parents to pursue her studies, Doudna realized her love for organic chemistry, igniting her passion for unraveling molecular enigmas and solidifying her goal of becoming a chemist.
David MacMillan reflected on his childhood in a modest Scottish town, where his family’s initial doubts about academic ambitions transformed following his brother’s achievement in earning a physics degree. Initially inclined towards physics, MacMillan faced difficulties in that domain until he stumbled upon organic chemistry, which outlined a clear path ahead and rekindled his enthusiasm for research.
**A Moment That Set the Trajectory for a Nobel Prize**
MacMillan recounted his postdoctoral experience at Harvard, where the challenges of working with air-sensitive materials in asymmetric catalysis motivated him to explore more practical, accessible methods. This pursuit culminated in his groundbreaking work to develop reactions utilizing organic catalysts on standard laboratory benches.
Doudna described her transition to a PhD program at Harvard, where her initial hesitation about research directions was resolved through serendipitous encounters. She unearthed the potential of RNA research through discussions with Jack Szostak, which laid the groundwork for her future contributions to the discipline.
Yaghi shared his time as a visiting scholar in China, where collaboration with an undergraduate student resulted in the formation of a pivotal crystal structure that was crucial to his Nobel-recognized accomplishments with MOFs. This breakthrough underscored the significance of trusting one’s instincts and retaining seemingly unsuccessful experiments for future success.
**Advice for a Young Scientist**
Doudna highlighted the importance of building connections with inspiring individuals whose work resonates with one’s interests, creating “good chemistry” for collaborative achievement. Yaghi emphasized the value of reliable partnerships, noting that fruitful collaborations are built on mutual respect and shared objectives. He recounted the profound influence of a mentor’s advice to apply research to societal challenges, which significantly shaped his career path.
MacMillan recommended keeping the larger research team in mind when choosing mentors, pointing out the necessity of a nurturing environment that corresponds with personal values and interests for flourishing in scientific pursuits.
In summary, the Nobel laureates shared their individual journeys and insights, providing valuable lessons in perseverance, mentorship, and collaboration for budding scientists.