Revolutionising RSV prevention

It has been several decades since the monoclonal antibody Synagis (palivizumab) was approved as a preventative for severe disease caused by respiratory syncytial virus (RSV) infection. But it seems possible that, by the end of the summer, there will be three brand new therapies – including two vaccines and a long-acting antibody – approved for […]

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Photophysical oxidation plays newly discovered role in atmospheric chemistry

A newly discovered pathway for formaldehyde oxidation could be an important general mechanism in tropospheric chemistry. In the new route, absorption of sunlight allows organic molecules to react with atmospheric oxygen in a reaction that had not previously been observed. According to the researchers behind the findings, many compounds in the atmosphere are likely to […]

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Light-activated molecular motor drives drug delivery

A new drug delivery technique uses synthetic molecular motors to release a drug when activated by visible light. The proof-of-principle delivery mechanism, which was tested on cultured lung cancer cells, could enable a non-invasive, highly controlled and targeted way to activate drugs inside the body. Ben Feringa at the University of Groningen in the Netherlands […]

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Small ring insertion expands structural editing toolbox

A photoredox-induced radical pathway is behind a synthetic strategy that allows users to insert a small ring into a heterocyclic parent ring. Frank Glorius from the University of Münster in Germany, who developed the method with Kendall Houk at the University of California, Los Angeles in the US, compared it to sleight-of-hand magic. ‘Maybe a […]

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Frustrated radical pairs cleave unactivated C–H bonds

Pairs of frustrated radical species can selectively activate carbon–hydrogen bonds that were previously inaccessible with existing methods. The reagents are easily tuned, allowing them to target different C–H bonds on substrate molecules as required. Reactions that activate aliphatic C–H bonds are very useful in organic chemistry, but the stability of these ubiquitous bonds makes selective […]

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UK public sector scientists end strike action

The Prospect union, which represents over 150,000 science and technology workers in the UK, has called off its national strike action after reaching a deal with the government. The agreement includes a one-off cost-of-living payment and new commitments on potential redundancies. Prospect members took industrial action earlier this year in a dispute over pay, working […]

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Peptide analysis reveals truth of Seville’s ‘Ivory Lady’

The highest status individual in copper age Iberian society was a woman, not a man as was previously believed. The discovery is the result of an analysis of peptides extracted from tooth enamel taken from ancient remains found in a tomb in southern Spain. In 2008, the remains of an unusually high-ranking individual were discovered […]

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Nanocapsule seamed by calcium ions boasts huge internal volume

Researchers in the US have synthesised and crystallised a metal–organic capsule with an internal volume of 3500Å3.1 C-alkylpyrogallol[4]arenes have previously been assembled into dimeric and hexameric capsules with a range of metal ions both in the solid state and in solution. Ten years ago, researchers reported solution-phase evidence of a dodecameric capsule assembled with holmium, […]

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Repercussions of Bhopal disaster found to echo on down through generations

The 1984 Bhopal disaster that exposed thousands in the Indian city to toxic methyl isocyanate has had long term, intergenerational effects on victims, a new study has found. Researchers from the University of California, San Diego note that multiple studies have shown a broad spectrum of serious long term and chronic health effects for hundreds […]

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