Deletion of single gene promotes growth of functional lymphatic valves

A University of South Florida (USF Health) preclinical study unexpectedly identified the gene Foxo1 as a potential treatment target for hereditary lymphedema. The research, published July 15 in The Journal of Clinical Investigation, was done with colleagues from Tulane University and the University of Missouri. Lymphedema — a chronic condition in which lymphatic (lymph) fluid accumulates in soft tissue under the skin, usually […]

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Expressive writing reduces relationship conflict and aggression during pandemic

Individuals who wrote about their relationship troubles during the pandemic from the point of view of a neutral observer had less conflict and aggression with their partner, according to new research from USF’s St. Petersburg campus. Led by Associate Professor of Psychology Lindsey Rodriguez, the study surveyed 716 American adults across the U.S. and at […]

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Epilepsy surgery may improve overall brain health

Epilepsy surgery may be associated with improvements to overall brain health, a study led by University of Liverpool researchers has found. The study, published in Neurology®, the medical journal of the American Academy of Neurology, used advanced magnetic resonance imaging (MRI) techniques to inform its findings. Corresponding author Dr Christophe de Bezenac said: “Many clinicians remain hesitant […]

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New insights into how the ‘first brain’ works in the gut

New research explains how the nervous system in the gut, known as the enteric nervous system (ENS) causes propulsion along the gut, highlighting how similar it behaves to other neural networks in the brain and spinal cord. The study, led by Professor Nick Spencer at Flinders University, maintains that the ENS in the gut is […]

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Beige fat ‘indispensable’ in protecting the brain from dementia

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia. They have found that beige fat cells, which are typically intermingled with white fat cells in the […]

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Block by block: Researchers use Minecraft to advance artificial intelligence

Steve may be able to saw wood, make tools, explore caves or dig for precious stones, but the Minecraft avatar cannot understand that each of these steps build to the ultimate goal of obtaining diamonds. Alan Wagner, assistant professor of aerospace engineering at Penn State, and Sarah Rajtmajer, assistant professor of information sciences and technology, […]

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People who manage their asthma can improve their chances against COVID-19

Asthmatics who have their illness well under control have less severe COVID-19 outcomes than those with uncontrolled asthma, according to a large study conducted by USC and Kaiser Permanente Southern California. The findings, published in The Journal of Allergy and Clinical Immunology: In Practice, suggest that asthma patients — especially those who require clinical care — […]

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Renaissance Science – XVI

In terms of the books rediscovered from antiquity during the Renaissance one of those that had the biggest impact was Ptolemaeus’ Geōgraphikḕ Hyphḗgēsis, which became known in Latin as either the Geographia or Cosmographia. Claudius Ptolemaeus or (Klaúdios Ptolemaîos in Greek) is a scholar, who had a major impart on the development of the mathematical sciences in the second […]

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Neural network scours vast chemical space to design drug-delivering peptides

Large biomolecule drugs’ great promise is held back because it’s hard to get them into cells – but now US researchers have used machine learning to tackle this problem. They developed Peptimizer, a machine learning model that designs cell-penetrating peptides (CPPs) that improve oligonucleotide drug delivery into cells 50-fold. The teams of Rafael Gómez-Bombarelli and […]

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